Servicio Madrileño de SaludConsejería de Sanidad

Clinical Pharmacology


Welcome to this free website designed to optimize acenocoumarol treatment by mean of a clinical and pharmacogenetic algorithm. Recommendations of this web are based on data of a cohort of patients with thromboembolic disease, including clinical factors (age, sex, BMI, treatment with enzyme inducers and amiodarone) and information from four genes (CYP2C9, VKORC1, CYP4F2 and APOE). This algorithm explains 60.6% of the variability in dose required to achieve a stable INR (Borobia et al. PloS One, 2012*). This web site is not intended to substitute for care by a expert healthcare professional.


Initial Information
Choose your operation:
Acenocoumarol stable dose estimation Enter stable dose
(requires patient identifier)



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